Protein Details: Amiloride-sensitive sodium channel subunit beta

Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.

Sequence

PDB Structures

Ligand Binding